HK1 and heart failure: In addition, it has been claimed that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) that selectively inhibit COX2 increases the risk of heart failure, which may be associated with dysregulation of cardiac metabolism, and a significant increase in HK1 expression was found in the hearts of COX2-deficient rats, speculating that HK1 may be associated with altered cardiac energy metabolism during heart failure.