BAD and type 2 diabetes mellitus: U Rajamani et al. found that in diabetic patients, hyperglycemia activates HBP and leads to reduced BAD phosphorylation and BAD-Bcl2 dimer formation and accumulation, which mediates HBP-induced cardiomyocyte apoptosis and may be associated with myocardial contractile dysfunction during episodes of type 2 diabetes [182].