Not only that, but some researchers also claim that mitochondrial exposure to peroxynitrite (ONOO-) leads to tyrosine nitration of adenine nucleotide transferase (ANT) and VDAC1 and induces VDAC1 oligomerization, leading to the separation of HK2 from VDAC1 and ultimately to increased mitochondrial dysfunction and severity of myocardial infarction [39]. The gene discussed is VDAC1; the disease is myocardial infarction.