LDHA is a key enzyme in the glycolytic pathway, and researchers have found that in the presence of hyperglycemia, increased LDHA promotes the production of MMP2/9, stimulates extracellular matrix (ECM) degradation, and facilitates the transition of human aortic vascular smooth muscle cells from contractile to synthetic phenotype to attenuate AD progression. The gene discussed is LDHA; the disease is Alzheimer disease.