In addition, ZIKV infection significantly upregulates the expression levels of enzymes related to the glycolytic pathway, including PGAM1, and promotes cardiac fibrosis by impairing cardiac hypertrophy-associated proteins (e.g., RGS5, a GTPase activator), causing cardiac hypertrophy, which may lead to heart failure in infected patients [104]. Here, RGS5 is linked to cardiac hypertrophy.