PKM and myocardial infarction: In the hearts of patients with non-ST-segment elevation myocardial infarction myocardial infarction, nuclear translocation of PKM2 acts as a transcriptional regulator of pro-inflammatory genes and promotes transcription of cellular pro-inflammatory factors (e.g., IL6, IL-1β, and IFNγ), which cause myocardial injury [138].