Qiangxin recipe, a well-known herbal medicine, promotes the activation of a transcription factor called Krüppel-like factor 5 (KLF5) and increases the activity of the HK2 gene promoter, which induces glucose metabolism and inhibits cardiomyocyte apoptosis, providing a novel targeted therapy for the treatment of congestive heart failure [52]. Here, KLF5 is linked to congestive heart failure.