In addition, there was a higher ratio of CD4 T cells compared to CD8 T cells (3.33 vs. 0.71, p = 0.028; Fig. 4D) and a higher ratio of B cells compared to T cells (24.4 vs. 11.86, p = 0.028; Fig. 4E) in the non-tumorous tissue surrounding the central part of the tumor compared to the non-tumorous tissue surrounding the invasive front. This evidence concerns the gene CD8A and neoplasm.