TSC1 and renal cell carcinoma: On the other hand, mutations of TSC1/TSC2 and mTOR genes have also been found in some sporadic renal cell neoplasms including RCC with leiomyomatous stroma [13], ESC-RCC [14–16], chromophobe RCC [17], epithelioid angiomyolipoma/pure epithelioid PEComa [10], low-grade oncocytic tumor (LOT) [18, 19], and eosinophilic vacuolated tumor (EVT), among others [20, 21].