This is particularly notable in oncocytic tumors where analysis of cases that were not easily classifiable as typical oncocytoma and chromophobe RCC has led to the establishment of additional clinicopathologically RCCs or a broadening of the spectrum within previously known RCC subtypes [1] including eosinophilic solid and cystic (ESC)-RCC [2, 3], succinate dehydrogenase (SDH)-deficient RCC [4], low-grade fumarate hydratase (FH)-deficient RCC [5], MiTF family translocation RCC [6], and TFEB-amplified RCC [7, 8]. The gene discussed is TFEB; the disease is renal cell carcinoma.