TP53 and neoplasm: Comparing p53 mutant and wildtype within the HPV tumors, there is a significant difference in the presence of perineural invasion (p = 0.001); for all other variables tested (LVSI, grade of differentiation, FIGO stage, p16 status, tumor diameter, depth of invasion, tumor-free margin, age at primary treatment, and time to first local recurrence), no differences were found.