We screened these six DEGs and obtained five potential AD-related biomarkers, namely platelet endothelial cell adhesion molecule-1 (PECAM1), caspase 4 (CASP4), mixed lineage kinase domain-like pseudokinase (MLKL), APAF1-interacting protein (APIP), and histone deacetylase 6 (HDAC6), using the Lasso regression algorithm (Figure 4B). The gene discussed is HDAC6; the disease is Alzheimer disease.