AFP and hepatocellular carcinoma: Considering pre-defined cutoffs, GAAD had the highest rate of true positive detection across early-stage, late-stage and all-stage HCC, demonstrating higher sensitivity versus both the AFP and PIVKA-II assays (Supplemental Table 2, http://links.lww.com/HC9/A643; Supplemental Table 3, http://links.lww.com/HC9/A643).