In 2004, a Chinese study demonstrated that biannual screening with ultrasound and serum AFP could reduce HCC mortality by 37% in a population of 18,816 patients with HBV or a history of chronic hepatitis.28 While imaging is still at the foundation of HCC surveillance and diagnosis, and diagnostic algorithms based on serological biomarkers are likely to enhance existing diagnostic procedures rather than replace them, embracing algorithmic analytics may improve the efficiency of such diagnostic workflows. This evidence concerns the gene AFP and hepatocellular carcinoma.