The gender (biological sex), age, AFP, des-gamma carboxy-prothrombin (GAAD) algorithm (Roche Diagnostics International Ltd, Rotkreuz, Switzerland) is a novel in vitro multivariate diagnostic, which provides a semi-quantitative result based on gender (biological sex) and age, and 2 serological tumor markers, AFP and PIVKA-II. Here, AFP is linked to neoplasm.