CLDN1 and infection: Transcripts for HCV entry factors including cluster of differentiation 81 (CD81), occludin (OCLDN), claudin-1 (CLDN1), and scavenger receptor class B type I (SR-B1) were more highly expressed in organoids than in primary human hepatocytes with no consistent differences associated with infection status and at similar levels before and after differentiation (Fig. 1C).