ELN and cancer: In the extracellular matrix, LOXL2 activity promotes collagen, elastin (Añazco et al, 2016), and tropoelastin (Schmelzer et al, 2019) crosslinks, a phenomenon that is associated with the accumulation of the extracellular matrix, fibrosis, and inflammation, which are all typical hallmarks of cancer (Pickup et al, 2014; Chandler et al, 2019; Hanahan, 2022).