Interestingly, we found that protein levels of SREBP1 and ChREBP, 2 transcription factors that play critical roles in hepatic FA synthesis and steatosis, as well as FASN and ACC, 2 rate-limiting metabolic enzymes of DNL, were reduced in TRIM21-overexpressing livers compared with controls (Figure 5M). The gene discussed is TRIM21; the disease is steatosis.