SQSTM1 and metabolic dysfunction-associated steatohepatitis: Although the Trim21/p62/Keap/Nrf2 axis in Ad-Trim21 NASH livers seem not overtly dysregulated, it will be important to investigate in more depth this mechanism upon long-term Trim21 overexpression or silencing and to further investigate if other TRIM21 targets contribute to this phenotype.