Importantly, at age 32 weeks, when the NASH pathophysiology, including inflammation and fibrosis, becomes more apparent (Supplemental Figure 2, D–J), we found that TRIM21 induction reaches a plateau and is negatively correlated with A1CF protein expression and, subsequently, of KHK-C, due to aberrant splicing (Figure 2, B–E). This evidence concerns the gene A1CF and metabolic dysfunction-associated steatohepatitis.