SLC25A21 and colorectal carcinoma: In addition, treatment with 5-aza-2′-deoxycytidine (5-Aza-dC), a DNA demethylation agent, or the methyl group donor S-adenosylmethionine (SAM) led to an increase and decrease in SLC25A21 mRNA in CRC cells, respectively (Supplemental Figure 9).