KRAS and colorectal carcinoma: SLC25A21 overexpression significantly suppressed the proliferation rate and colony-forming capacity of KRAS-mutant CRC cells, M5 and SW620 (P < 0.01), but had a minimal effect on Caco-2 cells, a KRAS-WT CRC cell line (P > 0.05, Figure 2B and Figure 2C).