SLC25A21 and colorectal carcinoma: To determine the functional consequence of SLC25A21 downregulation in KRAS-mutant CRC cells, 2 KRAS-mutant CRC cell lines (M5 and SW620) and 1 KRAS-WT cell line (Caco-2), which have relatively low endogenous SLC25A21 expression, were used to establish stable SLC25A21-overexpressing cells upon transfection with the LV5-SLC25A21 lentiviral vector.