KRAS and colorectal carcinoma: In KRAS-WT CRC cells, both α-KG addition and Bobcat339 treatment changed the abundance of 5-hmC marks, whereas SLC25A21 knockdown only exerted a slight effect (Figure 7B), which was consistent with the extent through which SLC25A21 downregulation mediated mitochondrial α-KG efflux (Figure 4A).