The levels of p-AKT/p-ERK were increased and decreased in SLC25A21-depleted and SLC25A21-overexpressing CRC cells with KRAS mutation (Figure 5D and Supplemental Figure 7B), respectively, whereas no significant differences were found in KRAS-WT HT29 cells (Figure 5D). Here, SLC25A21 is linked to colorectal carcinoma.