Notably, in KRAS-WT CRC cells, SLC25A21 depletion also inhibited mitochondrial α-KG efflux to some extent, but the inhibitory effect was less substantial than that observed in KRAS-mutant cells, resulting in no significant downstream effects on Gln-derived α-KG to replenish the TCA cycle and biological function. Here, KRAS is linked to colorectal carcinoma.