Phytate modulates the transcription of genes encoding TNF and its receptors (TNFRI and TNFRII) in human colon cancer cells line (Caco-2), where the transcription of TNFRI is increased and of TNF and TNFRII reduced, showing an anti-inflammatory and antitumor role of phytate (27). Here, TNFRSF1A is linked to colonic neoplasm.