Analysis of TAM phenotypes in a mouse model of PC revealed that microbial ablation caused a reduction in immunosuppressive CD206 M2‐like TAMs and an elevation in M1‐like TAMs expressing greater levels of major histocompatibility complex class II (MHC‐II), CD86, TNF‐α, IL‐12, and IL‐6.38 The gene discussed is TNF; the disease is pachyonychia congenita.