Peptostreptococcus (P.)anaerobius activates the PI3K–AKT pathway in CRC, causing increased cell proliferation and activation of NF‐κB, increased IL‐10 and IFN‐γ expression, and recruitment of MDSCs, tumor‐associated macrophages (TAMs), and granulocytic TANs that are associated with chronic inflammation and tumor progression.227. This evidence concerns the gene AKT1 and neoplasm.