The main mediators of tumor‐induced polarization of macrophages from M1 to M2 types are chemokines and cytokines, such as prostaglandin E (PGE) 2, milk fat globule‐E8 (MFG‐E8), granulocyte/macrophage colony‐stimulating factor (GM‐CSF), CSF‐1, CCL5, IL‐4, IL‐6, and TGF‐β. The gene discussed is IL6; the disease is neoplasm.