Continuous exposure of the liver to multiple microbial products via portal circulation activates Fas ligand (FasL)‐sensitive CRC cells nucleotide‐binding domain, leucine‐rich‐repeat containing family, pyrin domain‐containing 3 (NLRP3) inflammatory vesicles and expresses IL‐18, which promotes NK cell maturation and initiates their tumoricidal function, and is an inhibitor of CRC metastatic growth in the liver.220. The gene discussed is FASLG; the disease is colorectal carcinoma.