Chenodeoxycholic acid (CDCA) is the strongest FXR ligand, followed by cholic acid, DCA, and lithocholic acid,176 and in an FXR‐dependent manner, gut microbiota stimulates excess weight and hepatic steatosis,179 whereas in hepatic FXR absence, elevated LXR expression and induction of LXR's lipogenic target genes, Scd‐1 and Fas, and elevated triglyceride and bile acid levels are observed.180, 181. The gene discussed is NR1H4; the disease is Hepatic steatosis.