PCSK6 and acute respiratory distress syndrome: Interestingly, LPS stimulation resulted in increased PCSK6 mRNA levels (Figure 1(a)), as well as elevated PCSK6 protein levels (Figures 1(b) and 1(c)) at 12 (196.07% and 179.06% of mRNA and protein levels at 0 hr, respectively), 24 (285.58% and 313.95% of mRNA and protein levels at 0 hr, respectively), and 48 hr (485.07% and 483.04% of mRNA and protein levels at 0 hr, respectively) after treatment, indicating upregulation of PCSK6 in the established ALI model.