Furthermore, the suppressor of ROS accumulation, SESN2, both its mRNA (OHSS n = 24, control n = 15) (P=0.003) and protein levels (OHSS n = 24, control n = 15) (P=0.038) were significantly increased in the granulosa cells of OHSS patients (Figures 1(a) and 1(b)). This evidence concerns the gene SESN2 and ovarian hyperstimulation syndrome.