The sensitivity and specificity of our DNN model compare favorably with other diagnostic tests used in cardiology, such as exercise electrocardiography to diagnose coronary artery disease (50), and exceed other medical screening tests, such as the BNP immunoassay for heart failure (AUC 0.60–0.70) (51), the Papanicolaou smear for cervical cancer (AUC 0.70) (52), and the CHA2DS2-VASc Score for stroke risk (AUC 0.57–0.72) (53). The gene discussed is NPPB; the disease is heart failure.