With a threshold p < 0.001, the results showed that the high-risk group showed higher resistance to 20 drugs, and the high-risk group was more sensitive to only one targeted drug, BI-2536 (Figure 11) [a small molecule inhibitor against PLK1 with a dual role in inducing apoptosis and impairing autophagy in neuroblastoma cells (Li et al., 2016)]. This evidence concerns the gene PLK1 and neuroblastoma.