These genes included NKX2–5, which is predicted to regulate aberrant gene expression in human MDS (28) and CLK2, a proposed oncogene in breast cancer (29); the promoters of both of these genes were hypomethylated in 15-month-old tet2m/m fish compared with 15-month-old tet2wt/wt fish. Here, NKX2-5 is linked to breast cancer.