The ten-eleven translocation 2 gene tet2, a dioxygenase enzyme that can catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine, is a recurrently mutated gene in hematological malignancies, including myelodysplastic syndrome (MDS) (1, 2). Here, TET2 is linked to hematologic disorder.