NFKB1 and cancer: Despite this, a thorough investigation into the potential uses of this therapy approach in cancer is warranted given the abundance of evidence connecting DA to cancer and non-tumor cells in the tumor microenvironment. Summarizing the prior empirical research on the reciprocal relationship between dopamine, we found strong evidence for strong anti-cancer activity of dopamine through the regulation of NF-κB in KB, colon cancer cells [24].