SMYD1 and Emery-Dreifuss muscular dystrophy: Sixty-two proteins were identified in both heart and muscle (examples shown in Figure 1), including chromatin regulators Smyd1 [adds the repressive H3K4me “mark” on histone H3 (Tracy et al., 2018)] and SetD2 [adds the H3K36me3 mark; (McDaniel and Strahl, 2017)], dystrobrevin-alpha [Dtna; (Aguilar et al., 2015)]; and Tmem38a (aka “Trimeric intracellular cation channel type A”), a nuclear membrane protein required for muscle-specific 3D genome organization (Robson et al., 2016) and genetically linked to Emery-Dreifuss muscular dystrophy (Meinke et al., 2020).