CSRP3 is a plausible EDMD candidate gene because Csrp3 is a mechanosensitive transcription regulator in muscle and cofactor for MyoD1 (Mathiesen et al., 2019), and also binds LC3 and promotes autophagy as a mechanism of protection against muscular dystrophy (Cui et al., 2020). This evidence concerns the gene CSRP3 and Emery-Dreifuss muscular dystrophy.