Mutations in LMNA cause over 15 genetically-dominant disorders including Emery-Dreifuss muscular dystrophy, cardiomyopathy, lipodystrophy, neuropathy, insulin resistance, “accelerated aging” disorders (e.g., Hutchinson-Gilford Progeria (Brull et al., 2018) and juvenile idiopathic inflammatory myopathy (Moraitis et al., 2015); see the Universal Mutations Database (http://www.umd.be/LMNA/). Here, LMNA is linked to Insulin resistance.