Lmcd1 is a Z-disc protein that responds to mechanical load (Luosujärvi et al., 2010), mediates cardiac hypertrophy (Frank et al., 2010), and is a shuttling transcription repressor that blocks the DNA-binding activity of transcription activator GATA6, which regulates lung and cardiac tissue-specific promoters (Rath et al., 2005). This evidence concerns the gene GATA6 and cardiac hypertrophy.