SPEG and ischemia reperfusion injury: Other novel candidates from heart included transcription factor Ndrg2, which protects against ischemia-reperfusion injury (Sun et al., 2013), several kinases (e.g., Speg, Skp1, Taok1, Sgk223), Pias2 (E3 SUMO-protein ligase), Mad1l1 (mitotic spindle checkpoint protein MAD1) and Ppp2ca (Ser/Thr-protein phosphatase 2A catalytic subunit alpha), which regulates an essential lamin-binding protein named Barrier to Autointegration Factor 1 (BANF1) and influences postmitotic nuclear assembly (Ahn et al., 2019).