BCL11A and thalassemia: In another study, specific SNPs in Xmn1 and BCL11A genes were correlated with Hydroxyurea (HU) response in Pakistani β-Thalassemia patients and found that although BCL11A polymorphisms were more prevalent in the Hydroxyurea (HU) responders, their association with HU response was not found to be statistically significant.12 Other studies investigated Xmn1 polymorphisms in Pakistani thalassemia patients using polymerase chain reaction.13-16