There were no significant differences in abdominal pain, fever, nausea and vomiting, fatigue, decreased albumin, PLT, WBC, elevated AST, and hand-foot syndrome between the two groups (P>0.05), while there were significant differences in hypertension, diarrhea, and gingival bleeding between the two groups (P<0.05; Table-IV). This evidence concerns the gene ALB and Hand-foot syndrome.