Neurogenic inflammation is caused due to the release of neuropeptides containing tachykinins (neurokinin B, substance P and neurokinin A) from the exhibiting part of the noncholinergic, nonadrenergic excitative nervous system after exposure to allergens.16 Neuropeptides, such as neurotrophins and tackykinins have been believed as fundamental intermediaries of neuro-immune associations in some autoimmune disorders.17 It is also reported that neuropeptides play a potential role in some autoimmune neuroinflammatory and systemic autoimmune diseases.18 Here, TAC1 is linked to autoimmune disease.