Of note, anti-TNF- α drugs have also been used to treat severe stages of liver disease, such as alcoholic hepatitis (AH), nonalcoholic fatty liver disease (NAFLD), refractory autoimmune hepatitis (AIH), and primary biliary cholangitis (PBC), which were contradicting with IFX -associated hepatotoxicity (62). This evidence concerns the gene TNF and primary biliary cholangitis.