Of note, anti-TNF- α drugs have also been used to treat severe stages of liver disease, such as alcoholic hepatitis (AH), nonalcoholic fatty liver disease (NAFLD), refractory autoimmune hepatitis (AIH), and primary biliary cholangitis (PBC), which were contradicting with IFX -associated hepatotoxicity (62). The gene discussed is TNF; the disease is metabolic dysfunction-associated steatotic liver disease.