CD4 and food allergy: Interestingly, a singular phenotype of Foxp3-IL-10-CD4+ T cells effective against Th2 responses in food allergy was claimed to be induced by DC differentiated in the presence of RA and exposed to TLR stimulation (67), illustrating that the modulation of RA, IL-10, and IL-27 levels by TLR ligands may modify the balance of Treg subsets with different properties (68, 69).