FOXP3 and food allergy: The involvement of Foxp3+RORγt+ Tregs in the mediation of oral tolerance in food allergy is further sustained by the finding that their frequency is reduced within peripheral blood mononuclear cells of allergic human patients and mice, despite normal frequencies of circulating RORɣt+ effector T cells, and by the enhanced susceptibility of mice with depleted Rorc (which encodes RORγt) expression to suffer vigorous anaphylactic responses (32).