Some studies have found that ipilimumab can induce Fc-mediated antibody-dependent cytotoxicity (ADCC)-mediated Treg cell reduction in Pancreatic cancer due to the infiltration of FcγR-dense myeloid cells in the tumor, which increases the sensitivity to CTLA-4 mAbs (120, 121). The gene discussed is CTLA4; the disease is neoplasm.