Links to poor outcomes have been observed for Tregs located near CD8+ T cells in HPV- oral squamous cell carcinoma (OSCC) (68) and in CRCs with microsatellite instability (75), and for both CD4+ and CD8+ Tregs located near non-small cell lung cancer (NSCLC) cells (76, 77). Here, CD4 is linked to non-small cell lung carcinoma.