The presence of TLSs has been linked to improved prognoses in a number of cancers, including melanoma (40), head and neck squamous cell carcinoma (41), pancreatic ductal adenocarcinoma (PDAC) (42), and muscle-invasive bladder cancer (43), and can have greater prognostic value than the bulk count of infiltrating CD8+ T cells (44–46). Here, CD8A is linked to melanoma.