In addition to TLR9 stimulated cytotoxicity of NK cells on B16 melanoma cells, the secretion of inflammatory cytokines as IFNγ and IL-12 was promoted via TLR7/8 activation, which in order aided the NK cells to eliminate the HNSCC cells and B16-F10 melanoma cancer cells (86–88). This evidence concerns the gene IFNG and head and neck squamous cell carcinoma.