Recent studies in tumors, such as multiple myeloma and glioblastoma, have shown positive relations between CXCL13 and CD206+ M2 macrophages (10, 50), supporting the notion that CXCL13 has chemotaxis to CD206+ M2 macrophages in the BAT which may play a beneficial role in brown adipocytes thermogenesis. Here, CXCL13 is linked to plasma cell myeloma.