Therefore, as NOTCH signaling can influence the differentiation and function of T lymphocytes (150, 151) and because novel emerging properties of the DLL4-NOTCH signaling pathway have recently been identified in pathology, notably in controlling the CD4+/CD8+, Th17/Treg balance both in experimental autoimmune uveitis and EAE (152, 153), studying the NOTCH pathway between astrocytic endfeet and infiltrated inflammatory cells is of particular interest to the field of neuro-immunology. Here, CD4 is linked to autoimmune uveitis.