NOTCH1 and amyotrophic lateral sclerosis: Strikingly, NOTCH1 signal transduction is reactivated in reactive astrocyte populations after intra-cerebral hemorrhage (13), in stroke (14) and in several neuro-inflammatory conditions such as amyotrophic lateral sclerosis (ALS) (15), MS and experimental auto-immune encephalomyelitis (EAE) (16, 17).