In conclusion, the present study picked up ten hub genes of ARDS related to autophagy and metabolism, namely ITGAM, TYROBP, ITGB2, SPI1, PLEK, FGR, MPO, S100A12, HCK, and MYC, which could cluster ARDS patients into different molecular phenotypes. The gene discussed is PLEK; the disease is acute respiratory distress syndrome.