Another protein that has been shown to interact with DERL1 is the mutated superoxide dismutase 1 (SOD1), which accumulates and misfolds in motor neurons in amyotrophic lateral sclerosis (134), another neurodegenerative disease, and the interaction with DERL1 is involved in the disease pathophysiology (135). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.