Carriers were further categorised into those who had a FDR with bowel cancer (FH+; n = 45 for MLH1, n = 39 for MHS2 and n = 114 for MSH6) and those who did not (FH-; n = 44 for MLH1, n = 32 for MHS2 and n = 307 for MSH6). Here, MSH6 is linked to intestinal cancer.