(26) indicated that IGF2BP2 regulates vasculogenic mimicry formation via promoting signaling through PI3K/AKT/mTOR axis in colorectal cancer (CRC), further supporting the importance of the IGF2BP2/miR-98-5p axis in promoting HNSCC progression by modulating PI3K/AKT signaling. This evidence concerns the gene IGF2BP2 and head and neck squamous cell carcinoma.