BMP4 and ovarian cancer: TMEM158 has been associated with an oncogenic role in ovarian cancer, increased cell proliferation, invasion, and adhesion by regulating the cell cycle cellular and proteins Transforming Growth Factor-β1 (TGFβ1), bone morphogenetic protein 4 (BMP4), adhesion molecule1 (ICAM1) and vascular cell adhesion molecule1 (VCAM1) (64).