CCND1 and neoplasm: At the same time, this tumor suppressor activity of TMEM88 was shown to be related to its downregulation that it exerts on the Wnt/β-catenin signaling pathway since the decrease in TMEM88 increased the expression of the active form of β-catenin and the transcriptional activity of TCF/LEF and in turn, the expression of its target genes c-Myc, and cyclin-D1, for which, TMEM88 could be studied for its use as an antitumor target (75).