SLC68A1 and neoplasm: High expression of TMEM180 is associated with a shorter lifespan in a patient with stage III colorectal cancer; it was also reported that in vitro and in vivo in mice, the SW480 colorectal cancer cell line showed tumor initiation ability, and this was positively associated with the level expression of TMEM180 so in colorectal cancer TM180 acts as an oncogene (85).