While other TMEM proteins are associated with a tumor suppressor function, for example, TMEM106A favors the decrease in cell proliferation and migration in kidney cancer and lung cancer (59, 60) even though it has been reported that some TMEM proteins can exert both functions in different types of cancer, such is the case of TMEM180 that promotes cell proliferation in colorectal carcinoma (11), while in pancreatic cancer act as a tumor suppressor gene (92). The gene discussed is TMEM106A; the disease is neoplasm.