Hypoxia favors an oncogenic role for TMEM45A in breast cancer cells and hepatocellular carcinoma cells, favors the chemoresistance to paclitaxel and etoposide through resistance to apoptosis in response to hypoxia in breast cancer MDA-MB-231 cells and hepatocellular carcinoma HepG2 cells respectively (21). This evidence concerns the gene TMEM45A and breast carcinoma.