In addition, an association between TMEM45A and the regulation of TGF-β in ovarian cancer is suggested because the knockdown of TMEM45A significantly decreased the levels of the TGF-β1, TGF-β2, RhoA, and ROCK2 proteins that participate in the signaling pathway of TGF-β signaling (23). This evidence concerns the gene TMEM45A and ovarian cancer.