It was shown that β-catenin and TMEM119 have positive feedback as β-catenin has 3 binding sites to the TMEM119 promoter, upregulating the expression of TMEM119 in breast cancer cells, and in consequence, TMEM119 promotes pluripotency of breast cancer cells in a β-catenin dependent manner (45). This evidence concerns the gene TMEM119 and breast cancer.