In cell lines HCT-8/5-FU and SW480/5-FU resistant to 5-fluorouracil (5-Fu), a chemotherapeutic used in the treatment of colorectal cancer, the protein and mRNA levels of TMEM45A were significantly elevated concerning parental cells HCT-8/5 and SW480 (28). The gene discussed is TMEM45A; the disease is colorectal cancer.