TMEM88 and neoplasm: It was demonstrated that the overexpression of TMEM88 conferred to the cells the ability to inhibit growth in vitro and in vivo, in addition to the fact that cell lines that overexpressed TMEM88 also reduced cell invasion and colony formation, while the decrease in the expression of TMEM88 with an shRNA favored cell growth and invasion, suggesting a tumor suppressor activity in thyroid cancer.