THBS1 and neoplasm: Studies have shown thatPRR13 is highly expressed in tumor tissues, and thrombospondin 1 (THBS1, synonyms:TSP1) may induce apoptosisvia CD47 following taxane-induced damage to the cellular microtube network[33–34]; up-regulation ofPRR13 confers resistance to taxanes by inhibitingTSP1[34–35].