MAPT and Alzheimer disease: The icv-STZ animals have been reported to manifest typical pathological features of AD such as extracellular accumulation of Aβ, tau hyperphosphorylation, neuronal loss, axonal damage, and demyelination in the hippocampus and fimbria [30, 60, 91, 97], reduced glucose uptake [43, 97] and oxidative stress [66, 91], without developing systemic diabetes.