Furthermore, Hostetler et al. reported that the median age at first aortic event (dissection, rupture, or elective aortic aneurysm repair) among patients with pathogenic SMAD3 mutation is 47 years, which is later compared with patients with TGFBR1 and TGFBR2 mutations [16]. This evidence concerns the gene SMAD3 and aortic aneurysm.