Specifically, previous studies have shown a significant increase in IGFBP7 expression in the lung tissue of patients with fibrotic lungs condition such as Systemic Sclerosis-associated fibrotic lung disease (SSc-FP) and Idiopathic Pulmonary Fibrosis (IPF), but not in those with SSc-PAH [31]. The gene discussed is IGFBP7; the disease is pulmonary arterial hypertension.