Here, we compare the activity of SU11248 and ABZ against AE in vivo with regard to the degree of angiogenesis and the expression levels of VEGFA, VEGFR2, and phosphorylated VEGFR2 (p-VEGFR2), to explore the effects of inhibiting angiogenesis on the development of AE. The gene discussed is VEGFA; the disease is acrodermatitis enteropathica.