Mice susceptible to lupus (Sle1.Sle3) showed a reduction in the expression level of VISTA on activated T cells and inflammatory monocytes in comparison to the control group [wild-type (WT)] mice, in which activation of T and myeloid cells and production of pro-inflammatory cytokines aggravated the progression of the disease [34]. The gene discussed is VSIR; the disease is systemic lupus erythematosus.