Hypermethylation of vimentin (VIM) [82], OSM4 [83], SEPT9 [84], GATA4 and GATA5 [85], NDRG4 [86], BMP3 [87], ITGA4[88], plus hypomethylation of LINE1 can be used as diagnostic biomarkers for early stage detection of CRC patients [89]. This evidence concerns the gene NDRG4 and colorectal carcinoma.