In tumor xenograft examination after RT, we found increased expression of Ki67 (1.58 ± 0.14) and reduced TUNEL-positive cells (0.23 ± 0.13) in HE-sEVs + IR treatment group in comparison with that in NE-sEVs + IR group or PBS + IR group with Ki67 (0.98 ± 0.12), (0.99 ± 0.21) and TUNEL-positive cells (1.06 ± 0.14) and (1.12 ± 0.10), respectively, indicating that HE-sEVs + IR treatment significantly reduced radiation-induced damage by increasing the cell proliferation and inhibiting apoptosis of the two CC cells ( Fig. 1I, J). This evidence concerns the gene MKI67 and neoplasm.