In contrast, a similar appearance of diffuse and global glomerular foamy changes without histiocytic infiltration is observed in several genetic and/or acquired enzymatic disorders, such as Fabry’s disease, lecithin-cholesterol acyltransferase (LCAT) deficiency, and lipoprotein glomerulopathy (LPG) [1–4]. The gene discussed is LCAT; the disease is lipoprotein glomerulopathy.