The use of probiotics to regulate the course of MG has already been validated in animal models, with a mixture of five probiotic strains (Streptococcus thermophilus, Lactobacillus reuteri, Bifidobacterium bifidum, Lactobacillus acidophilus, and Lactobacillus casei) observed to suppress pro-inflammatory lymphocyte reactions and reduce AchR antibody levels in MG model rats, and this effect is also achieved by increasing the number of Foxp3 + CD4 + Treg cells. This evidence concerns the gene CD4 and myasthenia gravis.