In addition to SNPs in the CSMD1 loci, IBI also identified a novel missense variant of rs1803274 in the BCHE loci, a novel intron variant rs948028 in the GRIK4 loci, and a novel missense variant of rs12779623 in the MALRD1 loci as the top-1 likely cause of HTN in 9, 2 and 1 HTN patients, respectively (Table 1). This evidence concerns the gene GRIK4 and hypertensive disorder.