To functionally assess the role of PDP1 in leukemia development in vivo, we transplanted (FLT3-ITD-positive) Molm13 cells transduced with either non-targeting control (NTC) or PDP1 shRNA expression vectors (Fig. 4F) into immunocompromised NOD/SCID interleukin-2 receptor gamma knockout (NSG) mice. Here, FLT3 is linked to leukemia.