During the pathogenesis of RA, Th17 cells produce various pro-inflammatory cytokines such as IL-17A and Granulocyte–macrophage Colony Stimulating Factor (GM-CSF), whereas T helper 1/2 cell (Th1/Th2) cells secret Interferon-γ (IFN-γ) and Interleukin-6 (IL-6), thereby promote synovitis [46]. The gene discussed is IFNG; the disease is rheumatoid arthritis.