As an example, a study of genetically predicted glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism in relation to CVD occurrence showed that the association of higher GIPR-mediated fasting glucose-dependent insulinotropic polypeptide levels with coronary artery disease risk was not driven by GIPR variants but was the result of LD confounding between variants at the GIPR locus and a variant in SNRPD2, an established coronary artery disease risk locus.16 The gene discussed is GIPR; the disease is coronary artery disorder.