These studies have demonstrated that LDL cholesterol (LDL-C), apolipoprotein B, and triglycerides were all associated with coronary artery disease and ischaemic stroke when assessed individually in univariable MR analysis.36,37 Nevertheless, only apolipoprotein B remained robustly associated with these CVDs in multivariable MR analysis with mutual adjustment for the other lipid-related traits.36,37. Here, APOB is linked to coronary artery disorder.