CDK4 and breast carcinoma: In this study, we conducted a comprehensive analysis across multiple ER+/HER2− breast cancer cohorts to evaluate the sensitivity of the MKShi/ERSlo subgroup to currently available treatments for ER+/HER2− early breast cancer, including chemotherapy with or without immunotherapy, and endocrine therapy with or without CDK4/6 inhibitors (CDK4/6i).