Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated that differentially expressed genes (DEGs) upregulated in the LE from patients with OLP encoded proteins that function in ECM receptor interaction, amoebiasis, PI3K-Akt signaling pathway, focal adhesion, hematopoietic cell lineage, protein digestion and absorption, and platelet activation (Fig. 1E). The gene discussed is AKT1; the disease is oral lichen planus.